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br Overall you do not really feel
2020-08-18
“Overall, you do not really feel like doing anything. Eventually it came back [energy]. I started feeling better and better, and I also got my appetite back. But before that I did not want to eat anything, do anything, or to meet up with anyone. You just do not feel like it”. (ID 5, 73-year-old ma
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br Validation of selected top associations between
2020-08-18
Validation of selected top associations between gene Erastin and drug response in the NCI-60 dataset After observing statistically significant associations (Table 1) between OCM gene expression and drug sensitivity in the 635 cell lines with available CCLE and GDSC measurements, we validated s
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br Conclusion The ACCI of patients with gastric cancer was
2020-08-18
Conclusion: The ACCI of patients with gastric cancer was associated with preoperative systemic inflammation. The ACCI combined with the NLR, which are commonly collected biomarkers, could enhance prognostication for GC patients. * Corresponding author. Department of Gastric Surgery, Fujian Medi
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br BRAF br Immunotherapy type
2020-08-14
3 BRAF 6 Immunotherapy type Abbreviations: PD-1 ¼ Programmed cell death protein 1; PD-L1 ¼ programmed death-ligand 1. to February 14, 2017 were analyzed. Patients known to have any previously controlled autoimmune disease were excluded. Before the data collection, all patients provid
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br A strength of our study
2020-08-14
A strength of our study is found in that our findings fill a void in the literature surrounding surgical menopause in endometrial cancer. We provide a comprehensive and qualitative analysis of one institution's experiences with surgical menopause in endometrial cancer patients aged 50 or younger.
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LGlutamine br Kent R Intelligibility in speech disorders
2020-08-12
[7] Kent R. Intelligibility in speech disorders. Amsterdam/Philadelphia: John Ben-jamins; 1992. [8] Yorkston KM, Beukelman DR, Tice TR. Sentence intelligibility test. Lincoln, NE: Tice technology services; 1996. [9] Auzou P. Les objectifs du bilan de la dysarthrie. In: Auzou P, Rolland Mon-
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br Several aptamers have already been developed against a
2020-08-12
Several aptamers have already been developed against a wide array of therapeutically relevant targets (Alshaer et al., 2018; Vandghanooni et al., 2018; Zhu et al., 2015). Among these, DNA aptamer AS1411 that targets the nucleolin protein has been extensively used as a cancer-targeting agent (Bates
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br In summary the evaluation of
2020-08-12
In summary, the evaluation of neoadjuvant therapy needs to rely on effective and reliable methods. Dynamic magnetic reso-nance imaging technology can not only provide information on the morphological changes of breast cancer lesions, but also reflect 1876-0341/© 2019 Published by Elsevier Limit
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br The cell invasion assay was carried out by using
2020-08-12
The cell invasion assay was carried out by using the BD BioCoat Matrigel™ invasion chambers with 8.0 μm pore PET membrane (BD Pharmigen TM, USA). Medium containing 10% FBS was added to the lower chambers and used as chemoattractant. MDA-MB-231 cells (2.5 × 105 cells/well) were resuspended in se
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br Morphological analysis of nano liposomes br TEM
2020-08-12
3.2. Morphological analysis of nano-liposomes TEM images detailed the formation of regular, consistent NLS as illustrated in Fig. 1(I). Fluorescence microscopy was employed to con-firm the restoration of NLS structure and subsequent conversion to NLBs. The fluorescence micrographs of the CHO-NL
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br Herein we reported novel NPs
2020-08-12
Herein, we reported novel NPs based on PEO-PBO-loaded LA-SN38 (EBNPs). The EBNPs with small size and narrow distribution, and could effectively control the release rate of SN38. Through in vitro cytotoxi-city and apoptosis assay, we demonstrated EBNPs were more effective in antitumor of human colo
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br Another characteristic of senescent cells is SASP
2020-08-12
Another characteristic of senescent Gilteritinib is SASP. Senescent cells usually express a persistent pro-inflammatory SASP, which affects the cellular microenvironment, leading to acceleration of aging and the initiation of age-related pathologies such as malignant cancers [43]. Many efforts hav
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br Conclusion br Anti cancer
2020-08-12
5. Conclusion Anti-cancer drug discovery and development are considered as the grand challenges for the pharmaceutical industry. Extremely dynamic mitotic-spindle microtubules indeed remain the most successful and promising targets for anti-cancer therapy. Microtubule-stabilizing agents are con
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br inflammatory drug br ZBTB is inversely correlated with
2020-08-12
inflammatory drug. 3.7. ZBTB46 is inversely correlated with SPDEF and positively correlated with PTGS1 in prostate cancer patients receiving ADT To study the relationships among ZBTB46, SPDEF, and PTGS1, we analyzed a prostate cancer TMA collected from the Department of Pathology, Duke Unive
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br Cognitive mediation model br This study also
2020-08-12
1.1.2. Cognitive mediation model This study also employed the Cognitive Mediation Model as another conceptual framework to better explain the pathways linking OHIS to health literacy. Whereas the Health Literacy Skills Framework is useful in explaining factors (e.g., OHIS) contributing to the d