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Mascot ID score br R ALPNNTSSSPQPK K
2020-07-27
Mascot ID score (R)ALPNNTSSSPQPK(K) (K)TYQGSYGFR(L) (R)ALPNNTSSSPQPK(K) (K)TYQGSYGFR(L) pre-mRNA for splicing and mutant protein expression, which in turn results in drug resistance in cancer cells heterozygously carrying TP53 R273H mutation. Both accumulation of genetic mutations and
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br Inhibition of HMGCR activity results in the
2020-07-27
Inhibition of HMGCR activity results in the depletion of intracellular sterol levels, which in turn results in the activation of SREBP2 [30,34]. SREBP2 resides in the endoplasmic reticulum (ER) in its precursor, full-length form. In response to sterol depletion, SREBP2 is escorted to the Golgi app
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br To our knowledge this is the first large scale
2020-07-25
To our knowledge, this is the first large-scale trial to explore specific changes of the gastric microbiota in GC stomach microhabitats using high-throughput sequencing techniques. Previous studies have found changes in the gastric microbiota across stages of gastric carcinogenesis in patients wit
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br and TRAIL mRNA was expressed
2020-03-24
and TRAIL mRNA was expressed during sub-culturing, but TRAIL pro-tein expression was not observed (Fig. 5E and F). These results suggest that serum-free high-density culture of stem A 61603 may induce IFN-β and TRAIL expression. Although nude mice co-injected with H460 tumor cells and 40K-ASCs
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br Fig Predicted risk of severe postoperative adverse events
2020-03-24
Fig. 2. Predicted risk of severe postoperative adverse events graded 3 þ according to Clavien-Dindo in relation to the preoperative change in serum testosterone. The curve describes the expected change in risk for severe postoperative adverse event with 95% confidence interval related to the preop
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br then allowing the patient to make the final
2020-03-24
then allowing the patient to make the final decision based on their own values and preferences. To explore preferred physicianepatient communication, the survey queried, “How would you have liked to discuss the decision to remove one or both breasts with your doctor?” The answer choices for
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Paxilline br Expression constructs br The A
2020-03-24
2.7. Expression constructs The A20 plasmids were purchased from Addgene (http://www. addgene.org/) and subcloned into pCMV-Myc and pCMV-Flag expres-sion vectors. A20 N-terminal DUB domain, C-terminal E3 ligase (ZnF1- 7) domain and their corresponding mutant structures as described were also su
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E mail addresses wangdujuan dlut edu cn D Wang
2020-03-24
E-mail addresses: [email protected] (D. Wang), [email protected] (Y. Jin). Survivability prediction, one of the three main tasks of cancer prognosis [20], predicts the outcomes (survival or death) of cancer patients. So far, most research defines ‘‘survival’’ as any incidence of cancer
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br Consensus biomarker score br The
2020-03-17
Consensus biomarker score The consensus biomarker score was generated by combining the results from three types of sample comparison: (1) tumor versus paired normal, (2) tumor versus healthy tissue of origin, and (3) tumor versus all healthy tissues. Comparison 1: primary tumor versus paired
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br Baseline characteristics br These studies
2020-03-17
3.1. Baseline characteristics These studies comprise a total of 1925 patients. Average age is 58.0 years old. Known genders amount to 1829 (74.9%) males, 382 (25.1%) females. Average documented survival of all patients included in this Talaporfin sodium (ME2906) study is 11.6 months. This does
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Pathologic analysis PA The resected specimens were histologi
2019-11-11
Pathologic analysis (PA). The resected specimens were histologically examined according to the Verbeke protocol by a specialized pathologist (author A.F.S.) who noted the tumor’s characteristics, including the ori-gin, differentiation grade, maximum diameter, presence of perineural invasion, lymp
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br Lauren P The two
2019-11-11
21. Lauren P. The two histological main types of gastric carcinoma: diffuse and so-called intestinal-type carcinoma. Acta Pathol Microbiol Scand. 1965;64:31e49. 24. Dasari BV, Roberts KJ, Hodson J, et al. A model to predict survival following pancreaticoduodenectomy for malignancy based on tumo
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br Furthermore the pathway analysis of the pre and post
2019-11-07
Furthermore, the pathway analysis of the pre- and post-treatment differential gene expression testing results using GSEA revealed over-representation of overlap with gene sets from the immunologic sig-natures gene set collection. Indicative overlapping gene sets include 4 sets specifically involv
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br induced MPTP opening may be
2019-10-21
induced MPTP opening may be related with the reaction of DN3 with the cysteine203 residue of CypD, further research is needed, however. Inaddition, recent studies have indicated that the anti-tumor effect of some ent-kaurane diterpenes is associated with p53 activation (Ma et al., 2013; Li et a